Severe cutaneous adverse drug reactions

Abstract Drug eruptions are among the most common diseases of skin. The majority cases benign and self-limited, however particular variants very severe potentially life threatening. A precise rapid diagnosis is essential but can be difficult in some instances as drug may lack specific histological criteria. Furthermore, pitfalls frequent heightened awareness to possible mimicry other skin required. This article focuses on three particularly dangerous forms cutaneous adverse reactions, namely acute generalized exanthematous pustulosis, reaction with eosinophilia systemic symptoms, Stevens-Johnson syndrome toxic epidermal necrolysis. As assessment alone insufficient establish diagnosis, special attention also paid clinical features differential diagnosis.